According to the American Academy of Orthopedic Surgeons, nearly 15 million people suffer with
Osteoarthritis (OA) of the knee. OA is the most common form of arthritis with pain and limited range of
motion being the primary symptoms and it is the leading cause of disability worldwide.

OA is a degenerative joint disease characterized by the breakdown and eventual loss of joint cartilage.
Cartilage is a protein substance that serves as a cushion between the bones of a joint. A normal knee glides smoothly because cartilage covers the ends of the bones that form the joints. With OA, the top layer of
cartilage breaks down and wears away, allowing bones under the cartilage to rub together.

OA generally manifests itself in three progressive stages and most often begins in the inside, or medial compartment of the knee, but may begin in the outside, or lateral compartment (early-stage). Untreated, OA in one compartment may progress into a second compartment of the knee causing increased pain and reduced mobility (mid-stage). When the disease ultimately affects all three compartments of the knee (late-stage), pain is often severe and treatment is generally limited to total knee replacement, an invasive procedure which removes the natural knee joint and replaces it with an artificial joint.

MAKOplasty® Partial Knee Resurfacing The MAKOplasty® procedure is indicated for patients suffering from unicompartmental or bicompartmental knee disease. Therefore, a total knee replacement (for tricompartmental knee disease) is sometimes necessary if your surgeon discovers during surgery that your knee has more damage than originally seen in the pre-operative X-rays and CT scan. Unlike total knee replacement, MAKOplasty® is a resurfacing of the joint with much less bone being removed. Soft tissues and ligaments remain untouched which allows for an overall less invasive procedure. MAKOplasty® partial knee resurfacing is an innovative treatment option for adults living with early to mid-stage osteoarthritis in the medial, patellofemoral or lateral compartments of the knee. It is powered by the RIO® Robotic Arm Interactive Orthopedic System, which allows for consistently reproducible precision in performing partial knee resurfacing. Surgeons use RIO® to perform MAKOplasty® through a smaller incision than that required for traditional total knee replacement surgery. During the procedure, the diseased portion of the knee is resurfaced, sparing the patient’s healthy bone and surrounding tissue. An implant is then secured in the joint to allow the knee to move smoothly again.
RIO® Robotic Arm Interactive Orthopedic System	MAKOplasty® partial knee resurfacing can: • Facilitate optimal implant positioning to result in a more natural feeling knee following surgery • Result in a more rapid recovery and shorter hospital stay than traditional knee replacement surgery • Be performed on an outpatient basis • Promote a rapid relief from pain and return to daily activities

Individual results may vary. There are risks associated with any knee surgical procedure, including MAKOplasty®. Your doctor can explain these risks and help determine if MAKOplasty® is right for you.