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MAKOplasty®

Corporate Overview

Founded in 2004, MAKO Surgical Corp. (NASDAQ: MAKO) is an innovative medical device company that markets both its RIO® Robotic Arm Interactive Orthopedic System and proprietary RESTORIS® family of implants to surgeons for a procedure called MAKOplasty® that provides a less invasive method for knee resurfacing and a new procedure for Total Hip Arthroplasty. The MAKOplasty® solution is comprised of technologies enabled by an intellectual property portfolio including more than 300 U.S. and foreign, owned and licensed, patents and patent applications.

MAKOplasty® is powered by the RIO® Robotic Arm Interactive Orthopedic System, a highly advanced robotic arm technology that assists your orthopedic surgeon in achieving consistently reproducible precision for the individual patient in knee and hip joint replacement.

MAKOplasty® Partial Knee Resurfacing is an innovative treatment option designed to relieve pain and restore range of motion for adults living with early to mid-stage osteoarthritis that has not progressed to all three compartments of the knee.

MAKOplasty® Total Hip Arthroplasty, is a new RIO® robotic arm application for those in need of total hip replacement. Advanced robotic arm technology and versatile implants assist surgeons in attaining a new level of accuracy and precision designed to restore mobility and active lifestyle.

The Evolution of MAKO Surgical Corp.

MAKO Surgical Corp. founded

November 2004

FDA clearance of the TGS robotic arm system

November 2005

First MAKOplasty® procedure performed

June 2006

Initial public offering

February 2008

FDA clearance of RESTORIS® UniCompartmental Knee System

June 2008

500th MAKOplasty® performed

August 2008

FDA clearance of RIO® Robotic Arm Interactive Orthopedic System and RESTORIS® MCK MultiCompartmental Knee System

December 2008

Peer-reviewed clinical publication Journal of Arthroplasty

December 2008

RIO® and RESTORIS®; MCK introduction

February 2009

1,000th MAKOplasty® procedure performed

March 2009

Lateral unicompartmental knee application introduction for the RIO® System

December 2009

8,656 MAKOplasty® procedures performed

June 2011

Launched the MAKOplasty® Total Hip Arthroplasty application for the RIO® system

September 2011